本品是由YSFluorTM 488标记的驴抗兔IgG(H+L)，使用抗原偶联的琼脂糖微珠从驴抗血清内亲和色谱纯化所得。免疫电泳和/或ELISA法检测显示本品特异性结合完整的兔IgG分子，也会与其他兔免疫球蛋白的轻链结合。可能会与其他物种免疫球蛋白发生交叉反应，但不会识别非免疫球蛋白类的血清蛋白。
YSFluorTM 488，Amax（最大激发波长）为493 nm，Emax（最大发射波长）为519 nm，同Alex Fluor 488和FITC的光谱性质一样，通常可考虑相互替代。本品适合做单标实验，广泛应用于多种免疫学实验如免疫细胞化学（ICC），流式细胞术（FC）等。要做多标（Multiple-labeling）实验，建议使用经过与相近物种血清蛋白或者免疫球蛋白预先经过亲和吸附处理的二抗。
-25 ~ -15℃分装保存，尽量避免反复冻融。
[1] Song Y, Ge X, Chen Y, et al. Mycobacterium bovis induces mitophagy to suppress host xenophagy for its intracellular survival. Autophagy. 2022;18(6):1401-1415. doi:10.1080/15548627.2021.1987671(IF:16.016)
[2] He XT, Li X, Zhang M, et al. Role of molybdenum in material immunomodulation and periodontal wound healing: Targeting immunometabolism and mitochondrial function for macrophage modulation. Biomaterials. 2022;283:121439. doi:10.1016/j.biomaterials.2022.121439(IF:12.479)
[3] Zhou WJ, Zhang J, Xie F, et al. CD45RO-CD8+ T cell-derived exosomes restrict estrogen-driven endometrial cancer development via the ERβ/miR-765/PLP2/Notch axis. Theranostics. 2021;11(11):5330-5345. Published 2021 Mar 11. doi:10.7150/thno.58337(IF:11.556)
[4] Peng J, Pan J, Wang H, Mo J, Lan L, Peng Y. Morphine-induced microglial immunosuppression via activation of insufficient mitophagy regulated by NLRX1. J Neuroinflammation. 2022;19(1):87. Published 2022 Apr 12. doi:10.1186/s12974-022-02453-7(IF:8.322)
[5] Li X, Jin Q, Yao Q, et al. Placental Growth Factor Contributes to Liver Inflammation, Angiogenesis, Fibrosis in Mice by Promoting Hepatic Macrophage Recruitment and Activation. Front Immunol. 2017;8:801. Published 2017 Jul 11. doi:10.3389/fimmu.2017.00801(IF:6.429)
[6] Zhao ZT, Wang J, Fang L, et al. Dual-responsive nanoparticles loading bevacizumab and gefitinib for molecular targeted therapy against non-small cell lung cancer [published online ahead of print, 2022 Jun 15]. Acta Pharmacol Sin. 2022;10.1038/s41401-022-00930-6. doi:10.1038/s41401-022-00930-6(IF:6.150)
[7] Song Y, Dong Y, Liao Y, Liang Z, Yao J, Zhou X. Apoptotic caspases suppress Mycobacterium bovis-induced IFN-β production in murine macrophage. J Infect. 2021;83(1):61-68. doi:10.1016/j.jinf.2021.04.014(IF:6.072)
[8] Zheng Y, Gao Q, Li T, et al. Sertoli cell and spermatogonial development in pigs. J Anim Sci Biotechnol. 2022;13(1):45. Published 2022 Apr 11. doi:10.1186/s40104-022-00687-2(IF:5.032)
[9] Lin C, Guo Y, Xia Y, et al. FNDC5/Irisin attenuates diabetic cardiomyopathy in a type 2 diabetes mouse model by activation of integrin αV/β5-AKT signaling and reduction of oxidative/nitrosative stress. J Mol Cell Cardiol. 2021;160:27-41. doi:10.1016/j.yjmcc.2021.06.013(IF:5.000)
[10] Zeng LP, Gao YT, Ge XY, et al. Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1 Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. J Virol. 2016;90(14):6573-6582. Published 2016 Jun 24. doi:10.1128/JVI.03079-15(IF:4.606)
[11] Lu LF, Zhou XY, Zhang C, et al. Ca2+ plays an antiviral role by increasing p53 expression to achieve protection against spring viraemia of carp virus infection. Fish Shellfish Immunol. 2020;102:449-459. doi:10.1016/j.fsi.2020.05.023(IF:4.581)
[12] Zhuang W, Yan Z. The S2-S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation. Front Physiol. 2021;11:604134. Published 2021 Jan 20. doi:10.3389/fphys.2020.604134(IF:4.566)
[13] Qu F, Song Y, Wu Y, et al. The protective role of Ephrin-B2/EphB4 signaling in osteogenic differentiation under inflammatory environment. Exp Cell Res. 2021;400(2):112505. doi:10.1016/j.yexcr.2021.112505(IF:3.905)
[14] Li X, Jin Q, Yao Q, et al. The Flavonoid Quercetin Ameliorates Liver Inflammation and Fibrosis by Regulating Hepatic Macrophages Activation and Polarization in Mice. Front Pharmacol. 2018;9:72. Published 2018 Feb 9. doi:10.3389/fphar.2018.00072(IF:3.831)
[15] Qiao C, Ye W, Li S, Wang H, Ding X. Icariin modulates mitochondrial function and apoptosis in high glucose-induced glomerular podocytes through G protein-coupled estrogen receptors. Mol Cell Endocrinol. 2018;473:146-155. doi:10.1016/j.mce.2018.01.014(IF:3.563)
[16] Liu LY, Shan XQ, Zhang FK, et al. YAP activity protects against endotoxemic acute lung injury by activating multiple mechanisms. Int J Mol Med. 2020;46(6):2235-2250. doi:10.3892/ijmm.2020.4759(IF:3.098)
[17] Ma Z, Li F, Chen L, et al. Autophagy promotes hepatic differentiation of hepatic progenitor cells by regulating the Wnt/β-catenin signaling pathway. J Mol Histol. 2019;50(1):75-90. doi:10.1007/s10735-018-9808-x(IF:2.937)
[18] Wang Q, Zhang Y, Zhang F, et al. Generation of a human induced pluripotent stem cell line (JSPHi002-A) from a patient with long-QT syndrome type 1 caused by KCNQ1 c.773A > T mutation. Stem Cell Res. 2022;62:102810. doi:10.1016/j.scr.2022.102810(IF:2.020)
[19] Wen J, Song J, He C, et al. Establishment of an iPSC line (CSUXHi003-A) from a patient with Waardenburg syndrome type Ⅱ caused by a MITF mutation. Stem Cell Res. 2021;51:102157. doi:10.1016/j.scr.2021.102157(IF:2.020)
[20] Wen J, He C, Feng Y, et al. Establishment of an iPSC line (CSUXHi004-A) from a patient with Waardenburg syndrome type I caused by a PAX3 splice mutation. Stem Cell Res. 2021;53:102300. doi:10.1016/j.scr.2021.102300(IF:2.020)
[21] Huang L, Cai C, Dang W, Lu JH, Hu GF, Gu J. Propyl isothiocyanate induces apoptosis in gastric cancer cells by oxidative stress via glutathione depletion. Oncol Lett. 2019;18(5):5490-5498. doi:10.3892/ol.2019.10875(IF:1.871)
