Cisplatin(顺铂,又称为cis-DDP、CDDP、cis-Diaminodichloroplatinum)是一种最有效的抗癌药物,用于治疗多种实体瘤,如卵巢癌和肺癌等,并用于辅助治疗神经胶质瘤。Cisplatin与DNA的嘌呤碱基交联,干扰DNA的修复机制,引起DNA损伤,激活多条信号转导通路,包括ERK、p53、p73和MAPK,其中对激活凋亡影响最大,诱导细胞凋亡。
Cisplatin从1978年起被FDA批准用作抗癌药物。
参考文献
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冰袋运输。粉末直接保存于-25~-15℃,有效期3年,短期使用可置于2~8°C保存。