SAHA又称为Vorinostat、L-001079038、MK-0683、Suberoylanilide Hydroxamic Acid。

SAHA是一种有效的HDAC抑制剂，作用于HDAC1和HDAC3。SAHA引起组蛋白H4高度乙酰化，抑制细胞增殖，并引起细胞周期阻断，改变细胞形态，如细胞质变大、扁平，因此抑制细胞生长。SAHA处理细胞后还会降低抗凋亡蛋白Bcl-xL和survivin蛋白表达降低。在体内，SAHA显著抑制裸鼠体内CWR22移植瘤生长。Genistein和Vorinostat 联合作用用抑制细胞增殖具有协同效应。

【该产品仅用于科研实验，不能用于人体】

参考文献

[1] Richon VM, et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci U S A, 95(6): 3003-3007 (1998).

[2] Butler LM, et al. Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo. Cancer Res, 60(18): 5165-5170 (2000).

[3] Munster PN, et al. The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces differentiation of human breast cancer cells. Cancer Res, 61(23): 8492-8497 (2001).

[4] Hockly E, et al. Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease. Natl Acad Sci U S A, 100(4): 2041-2046 (2003).

[5] Pei XY, et al. Synergistic Induction of Oxidative Injury and Apoptosis in Human Multiple Myeloma Cells by the Proteasome Inhibitor Bortezomib and Histone Deacetylase Inhibitors. Clin Cancer Res, 10(11): 3839-3852 (2004).

[6] Marks PA, et al. Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug. Nature Biotechnology 25(1): 84-90 (2007).

[7] Hrzenjak A, et al. Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo. Molecular Cancer 9: 49 (2010).

常温运输。粉末直接保存于常温，有效期2年。溶于DMSO。建议分装后-20ºC避光保存，避免反复冻存，至少可存放6个月。