Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.

Western

Western blot analysis of Mitochondrial Fission 1 Protein in various cell lines lysates using TTC11 / FIS1 antibody.

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded rat heart using TTC11 / FIS1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded rat heart using TTC11 / FIS1 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded mouse heart using TTC11 / FIS1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunofluorescence

Immunofluorescence analysis of Mitochondrial Fission 1 Protein in HeLa using TTC11 / FIS1 antibody,and DAPI (blue).