The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100

Western blot analysis of Proteasome subunit alpha type 6 in HepG2, Hela, 293T, Jurkat and A375 lysates using Proteasome subunit alpha type 6 antibody.

Immunohistochemistry analysis of paraffin-embedded Human colorectal cancer using Proteasome alpha 6 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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