Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

推荐稀释比 WB:1/500-1/1000;IHC:1/100-1/200;IF:1/50-1/200

Western blot analysis of Histone H2B (mono methyl K116) in Hela lysates using MonoMethyl-Histone H2B (Lys116) antibody.

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.