Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.

推荐稀释比 WB:1/500-1/1000;IP:1/20

Western blot analysis of Nicastrin in K562, rat Brain, 3T3, Hela lysates using Nicastrin antibody.

Store at 4°C short term. Aliquot and store at -29°C long term. Avoid freeze/thaw cycles.