α-Methyl-DL-tryptophan是一种色氨酸衍生物和选择性SLC6A14阻断剂。在ER阳性乳腺癌细胞中，它通过抑制mTOR来激活自噬与凋亡，并具有减轻体重的功效。

[1] Karunakaran S, Ramachandran S, Coothankandaswamy V, Elangovan S, Babu E, Periyasamy-Thandavan S, Gurav A, Gnanaprakasam JP, Singh N, Schoenlein PV, Prasad PD, Thangaraju M, Ganapathy V. SLC6A14 (ATB0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer. J Biol Chem. 2011 Sep 9;286(36):31830-8. doi: 10.1074/jbc.M111.229518. Epub 2011 Jul 19. PMID: 21771784; PMCID: PMC3173074.[2]Sivaprakasam S, Ramachandran S, Sikder MOF, Bhutia YD, Wachtel MW, Ganapathy V. α-Methyl-l-tryptophan as a weight-loss agent in multiple models of obesity in mice. Biochem J. 2021 Apr 16;478(7):1347-1358. doi: 10.1042/BCJ20210100. PMID: 33720280; PMCID: PMC8038855.