Dickkopf related protein 1 (Dkk-1) is the founding member of the Dickkopf family of proteins that includes Dkk-1, -2, -3, -4, and a related protein. Dkk antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes.

高纯度、高活性、低内毒素、高批间一致性

                                        SDS-PAGE

Human DKK1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

                                                  Bioactivity

Immobilized Human DKK1, His Tag at 0.5 μg/ml (100μl/well) on the plate. Dose response curve for Anti-DKK1 Antibody, hFc Tag with the EC50 of 5.1 ng/ml determined by ELISA.

-25 ~ -15℃保存，收到货之后有效期1年。
复溶后， -85 ~ -65℃保存，3个月有效期。