Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
产品数据
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Western blot |
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Western blot analysis of alpha smooth muscle Actin in rat Brain, C6, 3T3, Hela lysates using alpha Smooth Muscle Actin antibody. |
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IHC |
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IHC analysis of paraffin embedded Human colon cancer using alpha smooth muscle Actin antibody.High pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. |
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