PD 169316 (PD169316)是一种细胞可渗透的p38 MAP kinase选择性抑制剂，IC₅₀值为89 nM，可抑制TGFβ和Activin A信号传导，但不影响BMP4信号转导。PD169316对Enterovirus71具有抗病毒活性。PD169316剂量依赖性的抑制TGFβ诱导的Smad2磷酸化和核转位，进而促进TGF-β靶基因的表达。此外，PD 169316还具有潜在的抗病毒和神经保护作用。

参考文献

1Fu Y, et al. The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells. Biochem Biophys Res Commun. 2003 Oct 17;310(2):391-7.

2.Hu W, et al. Suppression of Nestin reveals a critical role for p38-EGFR pathway in neural progenitor cell proliferation. Oncotarget. 2016 Dec 27;7(52):87052-87063.

3.Kummer JL, et al. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. J Biol Chem. 1997 Aug 15;272(33):20490-4.

4.Zhang Z, et al. PD169316, a specific p38 inhibitor, shows antiviral activity against Enterovirus71. Virology. 2017 Aug;508:150-158.

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