Proinflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS, as well as infection with Gram-negative bacteria. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators.

稀释比 WB: 1/500-1/1000 IP: 1/20

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。

Q：可以识别cleavage caspase-11吗？

A：不能。