Cyclophosphamide hydrate (Cyclophosphamide monohydrate, NSC-26271, Cytoxan)，又称环磷酰胺水合物，一种抗肿瘤药，是氮芥类烷化剂，使烷基连接到DNA的鸟嘌呤碱基，导致链断裂并诱导突变，广泛用于癌症化疗。环磷酰胺水合物被细胞色素P-450酶激活，产生活性烷基化类，以产生细胞毒性。

参考文献

1.Schwartz PS, et al. Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. Mol Pharmacol. 2001 Dec;60(6):1268-1279.

2.Liu P, et al. Administration of cyclophosphamide changes the immune profile of tumor-bearing mice. J Immunother. 2010 Jan;33(1):53-9.

3.Chang TK, et al. Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines. Cancer Res. 1997 May 15;57(10):1946-54.

4.Harris RN, et al. Carbon tetrachloride-induced increase in the antitumor activity of cyclophosphamide in mice: a pharmacokineticstudy. Cancer Chemother Pharmacol. 1984;12(3):167-72.

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