普仑司特是一种高效、竞争性的选择性白三烯拮抗剂，它能抑制[3H]LTE4、[3H]LTD4和[3H]LTC4与肺膜的结合，其Ki值分别为0.63±0.11 nM、0.99±0.19 nM和5640±680 nM。
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英文别名 (English Synonym) |
Pranlukast |
|
中文名称 (Chinese Name) |
普鲁司特 |
|
靶点 (Target) |
Leukotriene Receptor |
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通路 (Pathway) |
Immunology/Inflammation |
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CAS号 (CAS NO.) |
103177-37-3 |
|
分子式 (Formula) |
C27H23N5O4 |
|
分子量 (Molecular Weight) |
481.5 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Obata T, Okada Y, Motoishi M, Nakagawa N, Terawaki T, Aishita H. In vitro antagonism of ONO-1078, a newly developed anti-asthma agent, against peptide leukotrienes in isolated guinea pig tissues. Jpn J Pharmacol. 1992 Nov;60(3):227-37. doi: 10.1254/jjp.60.227. PMID: 1491512.[2]Ogata M, Matsumoto T, Kamochi M, Yoshida SI, Mizuguchi Y, Shigematsu A. Protective effects of a leukotriene inhibitor and a leukotriene antagonist on endotoxin-induced mortality in carrageenan-pretreated mice. Infect Immun. 1992 Jun;60(6):2432-7. doi: 10.1128/iai.60.6.2432-2437.1992. PMID: 1587610; PMCID: PMC257177.
