磷酸索尼德吉（Erismodegib diphosphate）是一种高效、选择性的Smo拮抗剂，其对鼠源和人源Smo的IC50值分别为1.3 nM和2.5 nM。
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英文别名 (English Synonym) |
LDE225 Diphosphate; NVP-LDE 225 diphosphate; Erismodegib diphosphate; LDE225 diphosphate |
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中文名称 (Chinese Name) |
Smo拮抗剂 |
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靶点 (Target) |
Smoothened |
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通路 (Pathway) |
Stem Cell |
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CAS号 (CAS NO.) |
1218778-77-8 |
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分子式 (Formula) |
C26H32F3N3O11P2 |
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分子量 (Molecular Weight) |
681.49 |
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纯度 (Purity) |
≥98% |
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溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Irvine DA, Zhang B, Kinstrie R, Tarafdar A, Morrison H, Campbell VL, Moka HA, Ho Y, Nixon C, Manley PW, Wheadon H, Goodlad JR, Holyoake TL, Bhatia R, Copland M. Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Sci Rep. 2016 May 9;6:25476. doi: 10.1038/srep25476. PMID: 27157927; PMCID: PMC4860619.
