Ibutilide fumarate（U70226E）作为一种抗心律失常药物，通过阻断AT-1细胞中的快速激活延迟整流钾电流（IKr），显著延长心肌细胞动作电位时程。
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英文别名 (English Synonym) |
Ibutilide Fumarate |
|
中文名称 (Chinese Name) |
富马酸伊布利特 |
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靶点 (Target) |
Sodium Channel |
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通路 (Pathway) |
Membrane Transporter/Ion Channel |
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CAS号 (CAS NO.) |
122647-32-9 |
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分子式 (Formula) |
(C20H36N2O3S)2·C4H4O4 |
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分子量 (Molecular Weight) |
885.23 |
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纯度 (Purity) |
≥98% |
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溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Yang T, Snyders DJ, Roden DM. Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. Concentration-, time-, voltage-, and use-dependent effects. Circulation. 1995 Mar 15;91(6):1799-806. doi: 10.1161/01.cir.91.6.1799. PMID: 7882490. [2] Chugh SS, Johnson SB, Packer DL. Altered response to ibutilide in a heart failure model. Cardiovasc Res. 2001 Jan;49(1):94-102. doi: 10.1016/s0008-6363(00)00235-2. PMID: 11121800.
