Ripasudil（K-115, K115, K 115, Ripasudil Hydrochloride Dihydrate, 盐酸瑞舒地尔二水）是ROCK特异性抑制剂，能够抑制ROCK1和ROCK2的活性，其IC₅₀值分别为51 nM和19 nM。Ripasudil 是Rho激酶抑制剂，具有强效的降低眼压的效果，可用作青光眼和眼内高压的治疗。

参考文献

[1] Kaneko Y, Ohta M, Inoue T, Mizuno K, Isobe T, Tanabe S, Tanihara H. Effects of K-115 (Ripasudil), a novel ROCK inhibitor, on trabecular meshwork and Schlemm's canal endothelial cells. Sci Rep. 2016 Jan 19; 6:19640.

[2] Yamamoto K, Maruyama K, Himori N, Omodaka K, Yokoyama Y, Shiga Y, Morin R, Nakazawa T. The novel Rho kinase (ROCK) inhibitor K-115: a new candidate drug for neuroprotective treatment in glaucoma. Invest Ophthalmol Vis Sci. 2014 Oct 2;55(11):7126-36.

[3] Kamiya Takayuki, Omae Tsuneaki, Nakabayashi Seigo, et al. Effect of Rho Kinase Inhibitor Ripasudil (K-115) on Isolated Porcine Retinal Arterioles. 2020.

[4] Isobe T, et al. Effects of K-115, a rho-kinase inhibitor, on aqueous humor dynamics in rabbits. Curr Eye Res. 2014 Aug;39(8):813-22.

[5] Kotaro Yamamoto, Kazuichi Maruyama, Noriko Himori, et al. The Novel Rho Kinase (ROCK) Inhibitor K-115: A New Candidate Drug for Neuroprotective Treatment in Glaucoma. 2014, 55(11).

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃干燥保存，避免反复冻融。