GSK2334470 (GSK-2334470)是一种新型的PDK1抑制剂，其IC₅₀值约为10 nM，可抑制PDK1肽底物的磷酸化。GSK2334470 (1 μM)抑制Akt Thr308磷酸化和活性，并且还抑制S6K1、SGK1的活化。GSK2334470和PP242联合治疗可显著抑制肿瘤生长。 

参考文献

[1] Najafov A, et al. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. Biochem. J, 2011, 433: 357-369.

[2]. Yang C, et al. PDK1 inhibitor GSK2334470 exerts antitumor activity in multiple myeloma and forms a novel multitargeted combination with dual mTORC1/C2 inhibitor PP242. Oncotarget. 2017 Jun 13;8(24):39185-39197.

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