TG100-115是PI3Kγ/δ选择性抑制剂，IC₅₀分别为83 nM和235 nM。TG100-115对PI3Kα/β抑制效果不明显，IC₅₀值大于1 µM。TG100-115在心肌缺血/再灌注动物模型中表现出心脏保护作用，减少梗塞的发展并保持心肌功能。

参考文献

[1] Doukas J, et al. Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19866-71.

[2] Doukas J, et al. Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2009 Mar;328(3):758-65.

冰袋运输。粉末直接保存于-25~-15℃，有效期3年。建议分装后-25~-15℃干燥保存，避免反复冻融。