This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Western

Western blot analysis of GADD45 alpha in CHO-K1 lysatesand CHO-K1 transfected by GADD45 alpha His fusion protein lysates using GADD45 alpha antibody.