Ilomastat (GM6001)是一种强效的广谱MMP抑制剂,对多种MMP亚型（MMP-1/2/3/9）具有纳摩尔级的高抑制活性。
|
英文别名 (English Synonym) |
GM 6001 |
|
中文名称 (Chinese Name) |
伊洛马司他 |
|
靶点 (Target) |
MMP |
|
通路 (Pathway) |
Protease/Metabolic Enzyme |
|
CAS号 (CAS NO.) |
142880-36-2 |
|
分子式 (Formula) |
C20H28N4O4 |
|
分子量 (Molecular Weight) |
388.46 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Leppert D, Waubant E, Galardy R, Bunnett NW, Hauser SL. T cell gelatinases mediate basement membrane transmigration in vitro. J Immunol. 1995 May 1,154(9):4379-89. PMID: 7722295.[2]Schultz GS, Strelow S, Stern GA, Chegini N, Grant MB, Galardy RE, Grobelny D, Rowsey JJ, Stonecipher K, Parmley V, et al. Treatment of alkali-injured rabbit corneas with a synthetic inhibitor of matrix metalloproteinases. Invest Ophthalmol Vis Sci. 1992 Nov,33(12):3325-31. PMID: 1385350.[2]Schultz GS, Strelow S, Stern GA, Chegini N, Grant MB, Galardy RE, Grobelny D, Rowsey JJ, Stonecipher K, Parmley V, et al. Treatment of alkali-injured rabbit corneas with a synthetic inhibitor of matrix metalloproteinases. Invest Ophthalmol Vis Sci. 1992 Nov,33(12):3325-31. PMID: 1385350.
