Harmine (GMP)是一种GMP级别的小分子,可作为细胞疗法辅助试剂。它是一种天然DYRK抑制剂,具有抗癌和抗炎活性,并对5-HT2A血清素受体具有高亲和力。
|
英文别名 (English Synonym) |
Harmine |
|
中文名称 (Chinese Name) |
去氢骆驼蓬碱 |
|
靶点 (Target) |
PPAR,MAO |
|
通路 (Pathway) |
Protease/Metabolic Enzyme |
|
CAS号 (CAS NO.) |
442-51-3 |
|
分子式 (Formula) |
C13H12N2O |
|
分子量 (Molecular Weight) |
212.25 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Zhang L, Zhang F, Zhang W, Chen L, Gao N, Men Y, Xu X, Jiang Y. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells. Cancer Biol Ther. 2015,16(11):1585-92. doi: 10.1080/15384047.2015.1078021. Epub 2015 Sep 18. PMID: 26382920, PMCID: PMC4846143.[2]Zhong Z, Tao Y, Yang H. Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury. Mol Med Rep. 2015 Dec,12(6):7985-91. doi: 10.3892/mmr.2015.4437. Epub 2015 Oct 13. PMID: 26496827, PMCID: PMC4758275.
