Sacubitril hemicalcium salt (AHU-377)是一种有效的NEP抑制剂,同时也是抗心力衰竭药物LCZ696的组分之一。
|
英文别名 (English Synonym) |
Sacubitril hemicalcium salt |
|
中文名称 (Chinese Name) |
沙库必曲钙盐 |
|
靶点 (Target) |
Neprilysin |
|
通路 (Pathway) |
Protease/Metabolic Enzyme |
|
CAS号 (CAS NO.) |
1369773-39-6 |
|
分子式 (Formula) |
C24H28Ca0·5NO5 |
|
分子量 (Molecular Weight) |
430.52 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Voors AA, Dorhout B, van der Meer P. The potential role of valsartan + AHU377 ( LCZ696 ) in the treatment of heart failure. Expert Opin Investig Drugs. 2013 Aug,22(8):1041-7. doi: 10.1517/13543784.2013.797963. Epub 2013 May 10. PMID: 23663006.[2]Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J Med Chem. 1995 May 12,38(10):1689-700. doi: 10.1021/jm00010a014. PMID: 7752193.
